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September 3, 2009 {QB3) qed@qb3-UCSF, Entrepreneurs' Luncheon Seminar

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September 3, 2009 {QB3) qed@qb3-UCSF, Entrepreneurs' Luncheon Seminar

 
Killing Pain with Killer Snails:
 The Development of the Analgesic, Prialt®
qed@qb3 - UCSF
Thursday, September 3, 2009
12:00 to 1:00 pm
Byers Hall Room 212

Ziconotide is the first intraspinal analgesic approved in the U.S. (2004) for the management of severe chronic pain in more than two decades. Ziconotide, the synthetic equivalent of a 25 amino acid neuroactive peptide originally isolated from the magician's cone snail, is a potent, selective blocker of neuronal N-type voltage-gated calcium channels that mediate the propagation and processing of noxious stimuli by pain pathway neurons. Ziconotide has its own unique safety issues, but as a non-opiate analgesic, it does not suffer from many of the limitations of opiate analgesics. The safety and efficacy of ziconotide have been well documented in several clinical trials and, subsequently, through the experience of thousands of additional pain patients.  The history of the development and commercialization, as well as speculations on future uses of Ziconotide, will be discussed.

Dr. George Miljanich has been developing ion channel therapeutics, analgesics, and peptide-based therapeutics for more than 20 years.  As CEO at AIRMID, he leads the development of T-cell potassium channel blockers to treat autoimmune disorders.  Prior to AIRMID, he was Senior  Director  at Elan Pharmaceuticals, playing a key role in the clinical development, regulatory approval, and commercialization of the analgesic, PRIALT® (ziconotide.) Dr. Miljanich holds a BS and PhD in Chemistry from UC Berkeley and UC Santa Cruz,  respectively, and conducted post-doctoral research at UCSF with Prof. Regis Kelly. On the faculty at USC, he studied calcium channels and channel-blocking conotoxins.  Dr. Miljanich then moved to Neurex Corp. to translate these conotoxins into pharmaceuticals, contributing to the development of PRIALT from invention through Phase III trials.  With the acquisition of Neurex, he became head of analgesia research at Elan. Dr. Miljanich has authored numerous scientific publications and is an inventor on 15 U.S. patents.  He serves as a consultant to the pharmaceutical industry, is Vice President of the Toxinomics Foundation, and a member of the CONCO initiative.  The Foundation fosters development of toxin-based therapeutics and CONCO is a $12 million EU-based program for discovering and developing drugs from animal toxins.

 

Lunch provided, but space is limited so please reserve a seat at http://www.acteva.com/booking.cfm?bevaID=175891  

This email was sent to morgan@luminogenics.com by douglas.crawford@ucsf.edu
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